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KMID : 0644120040170020027
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Journal of Oriental Gynecology
2004 Volume.17 No. 2 p.27 ~ p.40
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Effect of Jeoje and Tongyu-tang except Cheonsangap on lactation in postpartum rat
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Cho Jung-Hoon
Jang Jun-Bock
Lee Kyung-Sub
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Abstract
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Objective :This study was conducted to investigate the effect of Jeoje( 蹄) and Tongyu-tang except Chunsangap on lactation in postpartum rat.
Materials and Methods :We used 18 weeks pregnant Spraque Dawley rats and administered the decotions of Jeoje and Tongyu-tang except Cheonsangap to rats (treated group) and normal saline to control group once in a day for 4days and 8days. Then we observed the changes of the body weight changes of postpartum rats and pup rats, level of serum prolactin, -casein m-RNA, WAP m-RNA and mammary gland tissue of postpartum rats.
Results :We found that the body weight changes of postpartum rats and pup rats and the level of serum prolactin in Jeoje treated group and Tongyu-tang except Chunsangap treated group showed no significant difference. In the level of -casein and WAP gene, Jeoje treated group and Tongyu-tang except Chunsangap treated group increased than control group. Mammary gland tissue of Jeoje treated group and Tongyu-tang except Chunsangap treated group showed significantly increased angiogenesis of blood vessle compared with the control group.
Conclusion :This study shows that Jeoje and Tongyu-tang except Chunsangap have an effect on lactation in postpartum rat. But the mechanism of it may be other way than the hormon pathway.
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KEYWORD
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Tongyu-tang except Chunsangap, Jeoje, lactation, prolactin, -casein, WAP, mammary gland tissue
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